Probably not. My second wife's youngest sister married a CPA who had the same philosophy as me:
"If you are not being audited, you are not trying."

Robbie, I finished my first cut and there is a couple places where you do the Home Office thing. If you have a business, and use part of the home to run it in, and do the business part in the beginning, it has a whole series of questions on space, mortgage and taxes etc, then calculates it. Then in the very back in deductions, is a section that asks specifically about the Home Office. It says to qualify you must have it for exclusive use, be required by your employer and exclusively for that. I think the difference is in whether you are using part of your home for your own home business, vs having a "Home Office" you work from.

I'm there now, though my office space is a whopping 144 sq ft. Good times.

My husband is a corporate CPA in taxes, but we have a small accounting business in the home - small businesses and such. We have a complicated Excel spreadsheet to keep track of the fact we have PCs in two rooms, a copy ;machine in another (spread the power use out) and we depreciate one car used for client visits. We also have a formula in the Excel sheet for pulling out a portion of the electric charge PC software purchases, telephone charge, etc. Of course, that is a long form return.

When we first got married and had an office in our living room, we actually deducted 25 sq ft of space. Now we both have our own separate commercial space. I still remember doing that home office deduction when we got started.