Yes.
It's that old saying that people want to cut spending but not thhings related to the military, SS, or Medicare. This post shows you can at least put a dent in with without touching those things that account for most spending.

I wondered about things like SBIR/STTR. It says cut those things, but wouldn't those agencies (most SBIR grants from DoD) invest in those same technologies but through the big contractors like Raytheon instead of SBIR-eligible companies? If yes, then people who won't tolerate any military cuts won't tolerate this either. It's really hard to cut the budget w/o affecting military or entitlements.

Which is why it's a good start. It's low-hanging fruit. What's also important is that these are all very politically viable actions - you're not trying to take on Obamacare, Medicare, or SS.

That looks like around 100 billion. It addresses about a fourth of the problem.

Cuts like these are necessary across the board to all government programs. However, I disagree with at least one of these. OPIC costs the American taxpayer absolutely nothing, and takes no money from the US government. It is entirely self-funded. It produces a net profit for the US Treasury, and it enables companies who otherwise could not do so to do exports of goods and services.