Excerpt:
"In March, Kevin McKernan, a molecular biologist, found DNA contamination in Pfizer’s mRNA Covid vaccines and published this in here and here. As soon as Kevin McKernan put out his paper on the presence of small fragments of SV40, the Factcheckers arrived to flood the scene with strawmen — declaring there’s no SV40 virus in vaccines — which is true, but no one said there was.

Now the presence of remnant DNA has been confirmed by two independent labs (Dr. Sin Lee and Philip Buckhaults) — so it wasn’t a freak finding or a mistake. It really is that bad. Indeed, Phillip Buckhaults set out to show the fears were overblown but instead, in astonishment, confirmed what McKernan found.

“My plan was to examine the vaccine to debunk the fear of SV40 being in the vaccine. … I checked them first by a PCR assay that uses primers against the vector, and lo and behold, it fired very hot. A very, very high signal. … and son of the gun, Kevin McKernan was right, this plasmid is present in the vaccine. I proved that there is NOT SV40 full virus, but there is plasmid DNA. And that plasmid does have a little piece of SV40 in it. “

— Phillip Buckaults interview with Maryanne Demasi

Plasmid DNA within bacteria.

A plasmid is a circle of DNA that’s a regular lab tool. In this case it contains about 10% of the SV40 virus, a virus that contaminated some polio vaccines around 1960, and has been the subject of many studies since. We find it in cancer cells, but did it cause the cancers? Academic opinion is divided (see the papers here). But the part of SV40 that’s in the plasmid is a potent part that amplifies or promotes whatever code follows it. Indeed, SV40 is used in gene therapy research — it makes a good vector. It’s such a good gene therapy tool that the residual DNA contaminant ought to be classified under gene therapy regulations instead of vaccination rules, says McKernan. He points out that there is an ongoing lawsuit in Australia with the TGA about this very issue.
...
The contaminants include not just a part of a monkey virus, but also antibiotic resistance, and also something called a 72 ACE pair enhancer which is apparently good for moving DNA into the nucleus (Oh no).

Mr. Jekielek: Let’s talk about what we know concretely. Please explain why you might have this SV40 promoter and enhancer in there in the first place.
Mr. McKernan: It’s a common tool used in the biotech industry to drive very aggressive expression of a gene. In this case, Pfizer has it in front of a neomycin resistance gene, which drives resistance for neomycin. The reason they want it there is so that they can grow this plasmid in E.coli. E.coli doubles every 30 minutes, so you can grow E.coli overnight and get gobs of this DNA. You then have to purify it from E.coli to make RNA out of it.
Fragments of DNA — especially ones packaged the right way — could integrate into our own genetic code. They may do nothing or everything depending on where they “land” in our 3.2 billion base genome. They may cause cancer if they land inside a key gene that usually protects us against cancer.

The concern is if this DNA integrates the genome, one portion of the SSV40 sequence is an SV40 promoter, a very strong promoter, which means it drives transcription wherever it lands in the genome. If this happens to drop itself in front of a proto-oncogene and drives a lot of expression off of a gene that’s known, if you hyper-express it and turn the cell cancerous, then we have a concern that DNA is in fact doing that.

Normally it’s difficult for loose bits of DNA to get near the nucleus of our cells where our DNA is kelp. But if the DNA is packaged up and has the right equipment, it can get there:

There are two concerns. There are promoters in this vaccine from SV40 and there’s an 72 ACE pair enhancer, which David Dean has shown is a very potent tool for moving DNA into the nucleus, and they’re right next to each other. If this DNA moves into the nucleus and it drags a promoter with it, and that integrates in front of a gene, it can disrupt gene regulation and potentially lead to the oncogenesis.

Pfizer hid the SV40 component from the EMA
This is a really bad look:

The really crushing thing here is Pfizer never disclosed the SV40 information to the EMA [European Medicines Agency]. They gave them a plasmid map of what the plasmid consisted of, with all of the features labeled, with the exception of the SV40 site.

They did that because they know the SV40 region is a very controversial base in its history in the vaccine field. The polio vaccines were contaminated with the full virus, not just these little components, but the full virus. The full virus has over 5,000 bases. The components we have are about 466 bases of the virus, but they’re arguably the most functional aspects of the virus’s genome for replicating and for gene expression.

The fact that they hid that this is in there from the EMA is a concern. We know from David Dean’s work that it’s used as a gene therapy tool, so it would clearly classify the residual DNA in the vaccines under the gene therapy regulations that we have in many jurisdictions.

Fragments of DNA that integrate may do nothing or everything depending on where they “land” in our 3.2 billion base genome. They may cause cancer if they land inside a key gene that usually protects us against cancer. All our cells have multiple layers of protection against cancer, but this may wipe one of them out."