Antihistamines and the remarkable story of the freakishly good treatment plan in Spain that no one mentions

Posted by freedomforall 1 month ago to Science
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"In March 2020 a group of doctors working in nursing homes in Toledo, Spain faced a new pandemic with no effective treatment plan. They figured out their own protocol as best they could with what can only be described as freakish success. In nearby Albacete when Covid struck 1084 nursing home residents, 303 of them died, a 28% fatality rate. But in Toledo, of the 90 patients in nursing homes under Doctor Blanco’s care, only 6 died, and they all died before the team figured out their own new treatment plan. Of the 84 residents who were then treated with antihistamines like Polaramine, all 84 would make it. Every single one, even though their mean age was 85.

It seems too good to be true. Antihistamines are used to calm an overactive immune system (itchy, sneezes and runny noses) but they are not known for their anti-viral activity, though it turns there is some.

And while the antihistamines are possibly very helpful, the whole treatment protocol was so much more, and also included nasal washes, antibiotics, and prednisone, as well as something called “respiratory physiotherapy”. Somehow these doctors, saints or geniuses, had figured out a combination that worked, and there was no obvious reason why it should be treated like a lucky freak and ignored while millions literally died, yet that of course is precisely what happened.

Another research group in Spain studied nearly 80,000 people to see whether there were patterns in who got infected the most often. Only a few things ended up being significant and one of those was histamine use. People using antihistamines were half as likely to catch covid. (Vila-Córcoles).

But make no mistake, their treatment plan was a lot more than just Polaramine, and the antibiotics and nasal washes would all be important too.

For example, azithromycin works against a lot of viruses:

Numerous studies describe a possible antiviral activity of azithromycin against viruses as diverse as influenza viruses (Orthomyxoviridae), rhinovirus (Picornaviridae) [10], respiratory syncytial virus (Paramyxoviridae) and zika (Flaviviridae) [11]. Tran et al.[12] demonstrated the possible mechanism of antiviral action of azithromycin that blocks internalization into human lung epithelial cells during the early phase of infection of influenza virus A(H1N1)/pdm09 in vitro.

But antihistamines have their own toolkit against viruses and cytokine storms:

Regarding antihistamines, in recent years molecules with antihistamine activity have been identified as having powerful antiviral properties, inhibiting the entry of certain viruses into the target cell, such as the Ebola virus (filovirus) [28], or the hepatitis C virus (flavivirus) [[29], [30], [31]], or by other mechanisms [32]. Several H1 receptor antagonists have demonstrated inhibitory properties on the production and expression of interleukins, chemokines, and other cytokines [33]. Specifically, cetirizine decreases interleukin production [34,35].

There’s a whole lot more in the paper, but right now I’m just thinking of all the times a doctor told me that antibiotics won’t help with a viral infection."

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  • Posted by $ Ben_C 1 month ago
    Clearly Spain does not have a branch of the FDA peering over the doctors shoulders declaring "IT'S NOT APPROVED." Wonder why so many breakthroughs occur over seas? Wonder why US companies do research over seas? Wonder why Europe has drugs we don't have? As Reagan said: the most dangerous words are "we are from the government and we are here to help."
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