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  • Posted by $ jlc 9 years, 1 month ago
    The article is not wrong per se, but it does somewhat misstate the purpose of factor VIII. Factor VIII is the traditional 'Hemophilia' factor, the lack of which causes problems in Tzarist princes. Factor VIII does not stabilize the clot; it activates factors X an V. Factors X and V change prothrombin to thrombin; thrombin is what is responsible for clipping the end off fibrinongen and making it fibrin. It is _fibrin_ that produces the net-like sticky strands that stabilize the clot. (You can see these strands if you touch a cut lightly, just as the bleeding begins to stop. See the pale yellow spiderwebby strands that stretch between your finger tip and the wound? Those are fibrin.) So, Factor VIII is a couple of steps away from the 'stabilizing the clot' part of the process. This makes me wonder why increasing the activity of Factor VIII by using a look-alike artificial analog is apparently so effective. I also wonder if the product can replace what is currently used for traditional hemophiliacs.

    I too am concerned about how long this substance stays in the body. But having spent many hours crossmatching blood to pour into the exsanguenating (love that word) bodies of accident victims, I would unhesitatingly use it - and the devil take the hindmost. Keeping the patient in that lovely state known as 'still alive' is paramount. The FDA and everyone else should back off and let this be authorized for emergency situations (and we will figure out the rest later).

    Yes, the economics of long life will totally destabilize our current system, XenokRoy. Are you really suggesting that we do NOT extend life because we don't know how to straighten out the social and financial implications? Not me! I want to live hundreds of years; if everyone else also lives that long, I have no complaint.

    Jan
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    • Posted by $ 9 years, 1 month ago
      Very informative and explanatory response - thank you!

      As for living 100+ years...I'm too curious about what is after life to worry if I will die in the next few minutes, few days, few weeks, few years. To me, death will be the great adventure, the definitive knowing. Living 100+ years, to me, feels so tiresome, tedious, and, if things continue as they have been, disappointing.

      my 2 bits.
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      • Posted by $ jlc 9 years, 1 month ago
        I am just the opposite. There are SO many things that I want to do! I could live for a very long time without running out of 'wonder'.

        As for the last inevitable adventure, I fear that my last thought will be, "OK. Now I find out the tru..." and then nothing. Because there is no thought without it being contained in life. (Not even time enough for an, "Oh SH!T".)

        I am glad that you found my explanation interesting. The coagulation cascade is a logical mess and I drool uncontrollably every time I look at it.

        Jan
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  • Posted by Owlsrayne 9 years, 1 month ago
    AJ that product was in Pop Sci magazine a month or two ago. I believe the article went a little further that the military is developing a soldier jumpsuit that would have the gell in it in case of severe open wound injury.
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  • Posted by starznbarz 9 years, 1 month ago
    My git kits contain several sealed plastic bags with varying amounts of flour in them, 1/3 to damn near full, cut open the bag just enough to cover the wound and tape the bag in place. I expect it works on all but arterial pumpers. Works pretty good if you cut your dogs nails into the quick also.
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  • Posted by Mamaemma 9 years, 1 month ago
    Whoa. I'd like to know how long this stuff hangs around in the bloodstream. And what the long term effects might be, especially for those who take blood thinners.
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    • Posted by $ root1657 9 years, 1 month ago
      I totally get your point, but I'm still left thinking that whatever long term effects there might be are nothing compared to the long term effects of bleeding to death.
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  • Posted by XenokRoy 9 years, 1 month ago
    I think the technology is cool but man as life expectancy increases I think its creating some real problems and strains our our medical and fiscal systems. keeping a much larger percentage of the population alive longer.

    What are the economic ramifications of this, can we support them?
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    • Posted by $ MichaelAarethun 9 years, 1 month ago
      Science would treat old age as a disease and treat it systemically until they could convince mother nature to make a change.

      Politicians would ask if there was anything in it for them.

      Those waiting for their inheritance would argue for very late term abortion.

      Moralists might say no right to kill anyone without a trial and a lawyer.

      People, like my Father, who prepared themselves sign a bunch of forms which ban any heroic measures or other measures beyond a certain point are also doing the right thing. Providing the law or the do gooders don't get in the way.

      Even with that it took him five years to be allowed to die. During that time he had to suffer the indignity of having his adult diapers changed or crapping on the floor as he tried to make it to the bathroom. Among other indignities.

      One of his last lucid statements was something along the lines "keeping people alive beyond the point of ridiculous or until they ran out of money is 'cruel but not unusual' punishment." He also made sure they couldn't pull the plug too early.

      Life expectancy however is adding more years. It comes from better health measures and treatments thanks to gerontology and geriatrics teaching Mother Nature the old are worth a longer life span.

      But not to the point it violates their own wishes. In that respect I agree with Oregon.

      As for Quik Clot or its other brand names one only has to attend major vehicle accident, serve in the combat arms or watch the sniper movie of some years ago starring former rapper Mikey Mike to see the value. Like eating grubs in a survival situation. You may get somewhat sick from the worms or whatever but it will get you back to proper medical care centers. I fail to see the argument against the use and carry fresh packets in two sizes on my boat or when out hiking, climbing, and camping. For First Trauma Aid it's the best thing since jiffy pop.
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      • Posted by XenokRoy 9 years, 1 month ago
        I do not disagree with you at all. I too would buy this product for my emergency kits in all cars, get out bags and hiking bags in my house. Looks like a good product, and will allow many people to live that would have died in accidents only a few years ago.
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